Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone
نویسندگان
چکیده
منابع مشابه
Morning stiffness response with delayed-release prednisone after ineffective course of immediate-release prednisone
OBJECTIVE To assess morning stiffness in rheumatoid arthritis (RA) patients switched from immediate-release (IR) to delayed-release (DR) prednisone. METHOD Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) is a 12-week, randomized, multicentre, active-controlled study of morning stiffness that consisted of a double-blind phase and a 9-month open-label extension. Patie...
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Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of ...
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Since the demonstration of the potent anti-infl ammatory and immunosuppressive effects of glucocorticoids (GCs) halfway through the previous century, GCs have been the most frequently and generally used anti-infl ammatory and immunosuppressive class of drugs in a wide spectrum of immune-mediated diseases such as systemic autoimmune diseases, including the arthritides like rheumatoid arthritis (...
متن کاملCost-effectiveness of modified-release prednisone in the treatment of moderate to severe rheumatoid arthritis with morning stiffness based on directly elicited public preference values
BACKGROUND Assessing the cost-effectiveness of treatments in rheumatoid arthritis (RA) is of growing importance due to the chronic nature of the disease, rising treatment costs, and budget-constrained health care systems. This analysis assesses the cost-effectiveness of modified-release (MR) prednisone compared with immediate-release (IR) prednisone for the treatment of morning stiffness due to...
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Prednisone tablets are ineffective for the treatment of heaves, but dexamethasone preparations relieve airway obstruction within three to seven days. Prednisone is ineffective because it does not reach the blood as its active metabolite prednisolone. Authors’ addresses: Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824-1314 (Peroni, Jackson, Jefcoat...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Rheumatology
سال: 2015
ISSN: 0300-9742,1502-7732
DOI: 10.3109/03009742.2015.1038582